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In a comparative study the size dependency of BBB uptake and permeability was investigated for nanoparticles from 50 to 500 nm of various composition (polystryrene, protein, lipid) on a human culture BBB model in which transferrin nanocarriers with 500 nm diameter showed the most successful BBB penetration [61]

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Acknowledging these limitations is essential for contextualizing findings and guiding subsequent research toward rigorous, unbiased evaluation of GLP-1 RAs as gerotherapeutics within geroscience

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However, if the dose is too high (over-replacement), patients may experience: Palpitations, rapid heartbeat, or chest discomfort Tremor, nervousness, or anxiety Heat intolerance and excessive sweating Insomnia or sleep disturbances Unintentional weight loss When taking both medications together , it is important to distinguish between side effects attributable to each drug