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Andreozzi P, et al

Although GLP-1 and GIP are often grouped together as incretins, their receptors are encoded by different genes, recognise different ligands, and show different tissue distributions a clear illustration that related does not mean identical

Additional screening and caution considerations Other medical situations that require careful evaluation include: History of pancreatitis GLP-1 receptor agonists are generally used with caution in people with a history of treated pancreatitis

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Miyazato, M., K

However, the downregulated proteins exhibited enrichment in metabolic pathways, particularly the catabolic process ( p adjusted = 0.0011), cellular catabolic process ( p adjusted = 0.0006), and cytoplasmic translation ( p adjusted = 3.2E-07) (Supplementary Figure S6C