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doi: 10.1002/PEI3.10092 194 NetshimbupfeM

Contribution of the gut microbiome to drug disposition, pharmacokinetic and pharmacodynamic variability

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has been found to decrease the count of Th17 positive cells, lower the expression of IL-17 in the bloodstream, enhance the anti-inflammatory effect of IL-10, and restrain the IL-1 and TNF- levels in both the bloodstream and tissues (65)

These findings indicate that m imbalance not only disrupts oxidative phosphorylation but also alters substrate flux, linking mitochondrial bioenergetics to systemic metabolic signatures

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