It is worthwhile to note in both studies all participants were prescribed a reduced calorie (500 kcal/day deficit) and increased physical activity 150 min/week) regimen, which was insufficient to help preserve the initial weight loss
Another important factor is the presence of underlying health conditions
Vitamin B12 (Cobalamin) : Keeps nerves healthy, helps make red blood cells, and converts food into energy
Both injections and oral supplements are generally safe, but very high doses of B12 can cause side effects in rare cases, such as mild digestive issues or headaches
According to Nasri et al
Your weight loss trajectory on semaglutide depends on dose, diet, activity level, metabolic factors, sleep quality, stress management, and medication adherence, in addition to injection technique