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One of the primary mechanisms through which IGF-1 LR3 promotes muscle hypertrophy is by stimulating protein synthesis

J.Nutr.Health Aging 2010;14(3):224-230

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(Net flow by simple diffusion is always downhill, that is, from a high concentration to a low concentration.) The channels are created by the circular arrangement of 12 or more membrane-spanning regions of a single protein termed a transporter