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This is important because it indicates that any increase in systemic GLP-1 levels (for example through medication) could potentially influence the amount that reaches the joint. Tue Wenzel Kragstrup, MD, PhD The next step (in this research) is to find out whether GLP-1-based drugs reach the joints in high enough concentrations to have biological effects there, Kragstrup continued

The trial included roughly 450 adults with obesity or who were overweight and had knee osteoarthritis

The body appears to develop some tolerance to the GI effects with consistent exposure

The GLP-1 shortage challenges are exacerbated by a lack of accurate, up-to-date, and accessible GLP-1 supply information, Ro co-founder and CEO Zachariah Reitano said in a press release

Ratzke and Gore, 2018)

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