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The FDA classifies SNAC as Generally Recognized as Safe (GRAS) for use in humans

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Gastrointestinal side effects like nausea and vomiting are most common during the first 2-4 weeks after each dose increase, typically resolving as the body adapts to the new level

Overall, GLP1 agonists show central effects on brain regions involved in energy balance and cognition and may act in parallel to, rather than simply downstream of, insulin to modulate neuronal activity and glucose utilization

(Lond.) 35(Suppl