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Cartilage destruction in RA is closely linked to the oxidative stress environment, and the hypoxic environment increases monocyte differentiation toward osteoclasts and elevates osteoclast activity (39) ( Figure 3 )

Dietary and supplemental lipoic acid Consumption of lipoic acid from food has not yet been found to result in detectable increases of free lipoic acid in human plasma or cells (3, 6)

Popiech E, KuklaBartoszek M, KarowskaPik J, et al

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Selected drugs from Table II (including acetylsalicylic acid, atenolol and nicotine) are discussed as examples in the following section due to their widespread use as therapeutic agents in clinical practice