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Results: Overall, 6,633 patients were included, with Asian region contributing more than half of cases, LATAM sites with 496 patients (Table)

Real-time quantitative PCR was carried out on the CFX384 Touch Real-Time PCR Detection System (BIO-RAD)

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La precocidad de la separacin de las curvas de aparicin de MACE entre los brazos de SEMA y placebo23 sugiere una potencial participacin directa de SEMA en los resultados del estudio SELECT, a travs de efectos promotores de angiognesis y reduccin de estrs oxidativo e inflamacin, en el contexto de acciones antiaterognicas derivadas de la activacin del GLP-1R que favorecen la funcin endotelial y la supervivencia celular7 (fig

Achieving body weight loss of 515% can improve cardiometabolic parameters including prediabetes, dyslipidemia, and hypertension [5, 9]

Whilst not explored in detail in the latter project, we observed that the addition of a C-terminal acyl chain further influenced the ability of each ligand to recruit G proteins and -arrestins to the GLP-1R, highlighting this feature as a modifier of GLP-1R efficacy in its own right