N Engl J Med 2015;373:2247-57.ArticlePubMed 64
These medications help patients control their appetite and blood glucose levels more effectively, leading to improved weight management and better overall health
Tirzepatide, with a dual activity target GIP and GLP1 receptor, may have consequences for preventing or mitigating atherosclerosis due to its impact on GIPR activity
One particularly noteworthy association that stood out is the significant risk reduction across multiple gastrointestinal cancers, including colorectal, esophageal, stomach, gallbladder, liver and pancreatic cancers, Wang said
A FAERS-based pharmacovigilance analysis comparing tirzepatide vs semaglutide in female reports (Q1 2022Q3 2025) reported gynaecological haemorrhagic events in 0.62% of semaglutide cases (204 cases among 32,839 female-specific reports in that analysis) and did not detect a disproportionate signal vs tirzepatide
Veterans interested in semaglutide for weight loss should talk to their VA primary care provider or ask for a referral to their facilitys Move! weight management program
