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For weight management specifically, NICE technology appraisals TA875 (semaglutide 2.4 mg/Wegovy) and TA664 (liraglutide 3 mg/Saxenda) support their use as part of specialist weight management services, alongside dietary modification and increased physical activity

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This use was associated with the production of short-chain fatty acids, such as acetate 40

These outcomes lead to the remodeling of the extracellular matrix, oxidative stress, inflammation, cardiomyocyte apoptosis, fibrosis, and metabolic abnormalities [55]

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