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How does the potential impact of GLP-1 agonists on thyroid C-cells influence prescribing decisions for patients with a family history of medullary thyroid cancer or multiple endocrine neoplasia

Therefore, although several studies have reported that GLP-1 may be more useful in patients with preserved insulin secretory capacity [50, 51] and that insulin secretory capacity was not evaluated in the present study, more insulin-secreting and BW-reducing property of GLP-1RAs than DPP-4 inhibitors could partly explain the reason why rate of patients who achieved HbA1c values below 7% was higher in the semaglutide group than in the DPP-4 inhibitors group

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Obesity also stands as another significant risk factor

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