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The weight loss from bupropion alone is modest, typically 2-5% of body weight over several months, and it is often categorized as "weight-neutral" compared to other antidepressants rather than as a weight loss medication per se

For researchers prioritizing body composition over pure scale numbers, this data is compelling

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The potential for severe reactions, such as hormonal imbalances or increased blood pressure, further underscores the need for caution