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Together, these studies implied that GPx elevation may rescue the cells from radiation-induced mitotic death (G2/M arrest) but not from apoptosis

The bEnd.3 cells were then fixed with 4% paraformaldehyde (PFA) at room temperature for 1 h and stained with 4,6-diamidino-2-phenylindole (DAPI) at room temperature for 5 minutes

One explanation for the anti-tumour role of Nrf2 relies on its antioxidant capacity, which renders tumour cells less sensitive to drugs that induce oxidative stress overcoming the typically high ROS threshold of tumours

& Davies, S