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High-dose oral b12 (1000 to 2000 mcg daily) provides adequate absorption through passive diffusion even without intrinsic factor

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Vitamin deficiencies can lead to fatigue, sluggishness, and a decreased metabolism

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The first cardiovascular study of NNMT enzyme inhibition in a heart failure with preserved ejection fraction (HFpEF) mouse model demonstrated that treatment markedly reduced 1-MNA (by 77.1%), 2PY (by 66.2%), and 4PY (by 71.1%) in cardiac tissue, while improving cardiac function, enhancing global longitudinal strain, reversing peak longitudinal strain rate, and significantly reducing left ventricular hypertrophy and fibrosis