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The UPLC-QQQ/MS method demonstrated excellent linearity for IPA (r = 0.9999) across a broad concentration range, as detailed in Supplementary Data 4

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In senescent cells, FOXO4 binds to p53 within the nucleus, preventing p53 from initiating apoptosis and thereby allowing these dysfunctional cells to persist

CHAC2 itself is regulated both transcriptionally and post-translationally, with its degradation mediated by the ubiquitin-proteasome pathway ( In lung cancer, however, the CHAC2-mediated increase in ROS triggers the MAPK pathway

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Anaesthesia 63:8991 Temple AR, Benson GD, Zinsenheim JR, Schweinle JE (2006) Multicenter, randomized, double-blind, active-controlled, parallel-group trial of the long-term (612 months) safety of acetaminophen in adult patients with osteoarthritis