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[3] The scientists note that results together suggest that myostatin suppresses both basal and IGF-1-stimulated proliferation of both WAT and BAT preadipocytes, actions that are again similar to those in muscle satellite cells. Receptor Grade IGF-1 LR3, due to its speculated stability, may potentially counteract Myostatin by activating MyoD, a muscle protein normally triggered through prolonged physical strain

Bioactivity was determined using the IGF-1 LR3-responsive firefly luciferase reporter assay (B)

The Lancet , 402 (10402), 613626

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