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In this regards, it has been proposed to re-adapt our nutrition to the beneficial characteristics of our pre-agricultural diets [32]

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Faecalibacterium prausnitzii is markedly reduced, and fecal butyrate concentration is correspondingly decreasedchanges that likely contribute to constipation development ( As an HDAC inhibitor, butyrate upregulates tight junction proteins (occludin, claudins, ZO-1) and the mucin MUC2, reinforcing intestinal barrier function ( At the CNS level, butyrate crosses the BBB and upregulates BDNF expression, promoting neuroplasticity

doi: 10.1093/schbul/sbac065 120 NeryF

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