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TRAF6-mediated SM22 K21 ubiquitination promotes G6PD activation and NADPH production, contributing to GSH homeostasis and VSMC survival in vitro and in vivo

Pain was measured using the Knee Injury and Osteoarthritis Outcome Score measurement scale

Produced in the liver & kidneys, it plays an essential role in energy production

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J Chromatogr B 877:12291239 Kon K, Kim J-S, Jaeschke H, Lemasters JJ (2004) Mitochondrial permeability transition in acetaminophen-induced necrosis and apoptosis of cultured mouse hepatocytes