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ROS Overproduction: The Initiating Driver Hyperglycaemia activates multiple simultaneous ROS sources, including mitochondrial uncoupling, NADPH oxidase isoforms NOX2 and NOX4, and xanthine oxidase upregulation

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NICE guideline NG28 recommends GLP-1 agonists for type 2 diabetes when metformin and other oral agents prove insufficient, particularly in people with a BMI 30 kg/m (or 27