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This pathway has been beautifully illustrated by Krajnc et al
[DOI] [PubMed] [Google Scholar] 97.Microglial activation of GLP-1R signaling in neuropathic pain promotes gene expression adaption involved in inflammatory responses
& Daly, A
Wegovy is the same molecule at a higher dose (2.4 mg/week) approved specifically for weight management
These trials also demonstrated a significant reduction in C-Reactive Protein (CRP) levels, reinforcing the hypothesis that suppressing the pro-inflammatory state may yield substantial clinical benefits in this patient population
Questions regarding the cardiovascular safety of drugs prescribed for T2DM arose as individuals treated with sulfonylureas and insulin showed an increased incidence of major adverse cardiovascular events (MACEs: death from cardiovascular causes, nonfatal myocardial infarction, or nonfatal stroke) [18, 19]
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