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The additional GIP receptor activation further enhances energy balance and fat metabolism

Predesigned FAM TM dye -labelled TaqMan primers and probes were purchased from ThermoFisher Scientific

FIGURE 5 Exendin-4 Preserved Blood-Brain Barrier Integrity Through Glucagon-Like Peptide 1 Receptor/Activated Protein Kinase/Nuclear Factor-Kappa B Pathway To investigate the potential mechanisms of Ex-4 in BBB protection, Western blot was performed on the downstream proteins of GLP-1R at 24 h after SAH (representative images in Figure 5B)

Tirzepatide may indirectly affect fluid balance through weight lossaveraging approximately 15-22% in obesity trials without diabetes and more modest reductions in type 2 diabetes trials

Even if the molecule is the same, companies still need the relevant regulatory pathway and labelling for different uses