Blood samples were collected from the tail vein, and the blood glucose concentration was measured at 0, 30, 60, 90, and 120 min after administration using a LabGluco tester
, & Pratley, R
Denise D
Moreover, liraglutide 3.0 mg (i.e., the dose level approved for weight management for this GLP-1 RA) in combination with lifestyle intervention markedly reduced the presence of visceral fat over a period of 40 weeks ( The reductions in ROS and systemic inflammation, in combination with improvements in the other cardiometabolic parameters, are also thought to mediate the substantiated but so far formally unconfirmed kidney-protective effects of GLP-1 RAs, which may also directly or indirectly carry a HF-related benefit, considering that CKD is a prominent risk factor for HF (von Scholten et al., 2022)
Funding This work was supported by a The Swedish Research council to (2021-00220 to JER) and The Cure for Alzheimers Fund (2022 Galea Ciernia to LAMG)
The greater the weight loss and the shorter the time frame, the bigger the impact compared to more moderate or slower weight loss