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A 2025 meta-analysis in PMC (covering 36,754 tirzepatide and 106,057 semaglutide participants across multiple studies) confirmed tirzepatides advantage, finding an average 4.23 percentage points greater weight loss with tirzepatide an effect that was both dose- and duration-dependent

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Prices vary based on dosage and whether patients choose brand-name or compounded versions of semaglutide

Semaglutide is the active pharmaceutical ingredient that has helped thousands of people lose and maintain weight loss in combination with diet and exercise