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The UK Summary of Product Characteristics (SmPC) for Wegovy and the British National Formulary (BNF) list no direct pharmacokinetic interactions between semaglutide and antidepressants, including SSRIs like sertraline

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As shown previously ( Figures 2E

Lower Risk of Hypoglycemia Unlike insulin, GLP-1s only activate when your blood sugar is high

doi: 10.1172/JCI92407