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A change in TZD regimen from rosiglitazone to pioglitazone at specified, equivalent therapeutic doses was permitted at the investigators discretion if believed to be medically appropriate

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Hepatotoxicity Warn patients and guardians that nausea, vomiting, abdominal pain, anorexia, diarrhea, asthenia, and/or jaundice can be symptoms of hepatotoxicity and, therefore, require further medical evaluation promptly [seeWarnings and Precautions (5.1)]

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Do vitamin B12 shots interact with other medications or supplements

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Insulin exerts a vasodilatory action on the coronary vasculature to increase myocardial blood flow in humans

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Hypoxia disrupts the barrier function of neural blood vessels through changes in the expression of claudin-5 in endothelial cells

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