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These effects may include: Increased fat oxidation Improved energy balance Reduced fat accumulation However, more long-term research is required to confirm these benefits
In white adipose tissue of obese, insulin-resistant and aged mammals, NNMT is dramatically upregulated and because it consumes both the universal methyl donor (SAM) and the NAD precursor (nicotinamide), its hyperactivity simultaneously depletes the cellular methylation reserve and the NAD-salvage pool [1,2]
Since your body only absorbs a small amount at once, excess B12 just gets flushed out