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CT single or multiple hepatic metastatic lesions which may be hypervascular on the arterial phase and hypodense on the portal venous phase rim enhancement with central necrotic features is commonly seen hepatic melanoma metastases often demonstrate low attenuation when compared to normal hepatic parenchyma on CT MRI Findings are similar to those previously described for intracranial metastatic melanoma: T1: hyperintensity secondary to the melanin content of melanocytes care must be taken when diagnosing these lesions as other lesions can also demonstrate T1W hyperintensity due to associated hemorrhage PET-CT When combined with dedicated CT, it a sensitivity of 98% and a specificity of 94% for detecting metastatic melanoma

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Gene ontology (GO)/Kyoto Encyclopaedia of Genes and Genomes (KEGG) pathway enrichment analysis and KEGG pathway analysis Gene ontology and KEGG pathway enrichment analysis of differentially abundant proteins (DAPs) was performed with DAVID 156 with default parameters, using the BenjaminiHochberg-adjusted P -value threshold of 0.05