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10.1038/nrneph.2017.31 17 FonnumF

LX-2 cells in the lower chambers were collected for further analysis

Given the robustness of this mitochondrial response, the multifaceted nature of PGC1 regulation in cells and a modest rescue at best by mTORC1 inhibition, we suspect that there is a degree of functional redundancy built into this metabolic plasticity system that can contribute to such an adaptive response, and complete inhibition of this system will prove difficult

In a recent clinical trial, 40 Parkinson's patients complaining of constipation were treated with probiotics for five weeks

10.1146/annurev.nutr.24.012003.132418 7

Given the promising results in animal studies, clinical studies are required to evaluate the effect of sulforaphane on neurological outcomes in humans