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What the trials measured and when The METAOD005 oral trial measured weight at 12 weeks

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However, if factors such as the prescribed medications are negatively impacting B12 status then the frequency may well need to be increased to either 6-monthly or 3-monthly

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A decreased HoloTC level along with an increase in the size of the red blood cells (macrocytosis) is a good measure of vitamin B12 deficiency