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Effect of leptin therapy on survival in generalized and partial lipodystrophy: A matched cohort analysis

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1976;31 doi: 10.1093/geronj/31.1.8

We showed that mice fed a high-fat diet (HFD) for 12 weeks developed hepatic steatosis and liver injuries, which were associated with not only TNF overproduction but also hepatic glutathione dysregulation, characterized by GSH reduction and GSSG elevation