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An extremely high protein intake significantly increases the workload on the kidneys and can increase the risk of kidney stones

Most weren't followed after that, but researchers used modelling to estimate that risk markers for diabetes and heart disease, such as high cholesterol and high blood pressure levels, would return to pre-treatment levels in less than two years

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Patients with higher insulin resistance may benefit from advancing the dose more quickly to achieve metabolic benefits, while those with slower gastric emptying might need extended time at each level