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Targeting Aging with Metformin (TAME) trial is a double-blinded, placebo-controlled, multicenter trial that is planned to involve 14 research centers in the USA, and subject to funding and approval, will enroll 3000 ethnically diverse, non-diabetic subjects aged 6580 (60, 261)

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Adding the MIPS low volume threshold would mean that clinicians would have to meet the MIPS eligibility determinations as defined at 414.1305, as well as all other ASM participant eligibility criteria, to be identified as an ASM participant