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The commercialisation of GLP-1 receptor agonists (GLP-1s), also known as incretin mimetics, that enhance the response of the GLP-1 receptor, began nearly 20 years ago in 2005, with the launch of twice-daily injections of AstraZenecas Byetta (exenatide), followed by daily injections in 2010, with the launch of liraglutide (Victoza) from Novo Nordisk

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Together, the evidence indicates that addictive drugs alter DNA methylation across stress- and reward-related circuits, leading to lasting changes in gene regulation and behavior

ShapiroWilk test was used to check the normality of the variable distribution