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Some are rapidly broken down by enzymes in the body, while others are engineered for extended stability and slower clearance

Receptor activation stimulates intracellular cAMP production and downstream PKA-dependent signaling, driving glucose-stimulated insulin secretion, glucagon suppression, and gastric motility regulation

If you're taking a GLP-1 medication, consider cutting back or hydrating extra on the days you indulge

Metformin has been a long-standing high-value, low-cost agent for metabolic improvement without weight gain but needs progressive dose reduction as GFR falls to avoid nausea or diarrhoea, and should be ceased immediately if a patient is unwell

Even the maximum dose only requires 75 units

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