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TSH alone misses some patterns of dysfunction

164 ShimamuraM.SatoN.OshimaK.AokiM.KurinamiH.WaguriS.et al (2004)

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Then again at half-time, following half time, and following the entire simulation

Our current practice is to consider a ~20% bolus insulin decrease and a ~10% basal insulin decrease before GLP-1RA initiation, although prior A1c, risk of hypoglycemia, potential risk of ketosis due to reduced insulin doses, as well as other patient-specific factors should guide the final insulin dose changes

In the Phase 2 NEJM trial (2023), participants on 12 mg lost an average of 24.2% of body weight at 48 weeks