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And brand-name GLP-1s sit at a price point that may be out of reach for most consumers

Orlistat was linked to hepatotoxicity and adverse gastrointestinal events, sibutramine was associated with cardiovascular safety concerns, and lorcaserin was pulled from the market due to increased cancer risk

This safety update reinforces the importance of this guidance

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While an expired medication might not always be toxic, a loss of potency means your weight loss progress could stall because the drug is no longer effectively stimulating the GLP-1 and GIP receptors in your brain and gut

PMCID: PMC11589535