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The report shows that the number of 12- to 25-year-olds using any GLP-1 drug including older medications first approved to treat diabetes in 2005 and for weight loss in 2014 climbed from about 8,700 a month in 2020 to more than 60,000 a month in 2023, a nearly 600% increase

As of early 2026, the keratinocyte mechanism for GLP-1 facial aging specifically remains hypothesis-stage rather than settled

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Clinical trials using the Patient Health Questionnaire 9 (PHQ-9) found participants taking semaglutide, tirzepatide were 37% less likely to progress to more severe depression than those receiving placebo

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