TGP exhibits a wide range of pharmacological effects (Figure 2), but its mechanism of action in treating dermatologic diseases primarily relies on its anti-inflammatory, antioxidant, and immunomodulatory functions (Trsen et al., 2020)
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This may happen because calorie intake decreases, the body is adjusting to weight loss, fluid intake is reduced, or sleep quality changes
In conclusion, our study used scRNA-seq analysis, animal models, skin organoid culture and transplantation to show that PHB2 initiates mitophagy by binding to LC3 and selectively self-eliminates damaged mitochondria, promoting hair regeneration in mice
Notably, mitochondrial dysfunction, a hallmark of senescent chondrocytes in OA, induces intracellular ROS production that causes oxidative stress
As more patients are started on GLP-1 analogues, optometrists should be aware of the frequency of potential worsening retinopathy that occurs with rapid, improved glycemic control