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Br J Pharmacol 102 : 577580 Lafontan M and Berlan M (1993) Fat cell adrenergic receptors and the control of white and brown fat cell function

213 The DR nucleus is the largest and most significant conduit of forebrain serotonergic input

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Although each model differs in terms of CAG repeat length and transgene expression levels, and thus in the severity of the resulting HD phenotype, they were instrumental in demonstrating a fundamental feature of the disease, namely that severe neuronal dysfunction precedes degeneration and it is probably the primary cause of many HD symptoms 8,9