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We measured glutathione, glutamate and glutamine concentrations in the anterior cingulate cortex (ACC), left insula, and visual cortex using 7T proton magnetic resonance spectroscopy (MRS)

Importantly, SGLT2i have been shown to enhance heart functional capacity, as indicated by improvements in peak VO2 and performance in the 6-minute walking test (6MWT), both key metrics that reflect overall cardiovascular and metabolic health of patients

The first two 30-min samples were discarded to obtain stable basal values

the testing set was independent of the training process and was used only for performance evaluation after the model was established

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