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Another study found that people taking antidepressants with GLP-1s lost less weight than those not taking antidepressants

HYPOTHALAMIC CONTROL OF GLP-1 ACTIONS ON SATIATION AND SATIETY: ANIMAL STUDIES Ongoing studies imply that the usage of GLP-1R agonists can be expanded to other areas, beyond their conventional roles in controlling food intake or energy balance

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Later, higher-dose semaglutide was approved for chronic weight management