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134 , e175634 (2024)

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In murine models, the activation of GLP-1 receptors within the VTA has been shown to attenuate the synaptic strength of the VTA-NAcc pathway,154 although GLP-1 receptor expression in VTA neurons is relatively sparse.155 Rat studies indicate that GLP-1 receptor activation in the VTA can enhance dopaminergic neuronal activity via presynaptic mechanisms.156 Despite preclinical evidence and limited clinical trials, the precise influence of GLP-1 receptor stimulation on the effects of abused drugs and alcohol remains unclear

Islets from Gcg-GCaMP6f mice were typically isolated 10 days after tamoxifen induction