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Larger, longer-term studies are needed to establish durability and optimal dosing

PMID 40123442

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Examples include GPx1, the most abundant and ubiquitously expressed isozyme which functions to detoxify hydrogen peroxide (H 2 O 2 ) to nontoxic water (H 2 O) and GPx4, which has a strong affinity for lipid hydroperoxides and regulates ferroptosis (Figure 1)

Loss of PLA2G6 leads to elevated mitochondrial lipid peroxidation and mitochondrial dysfunction