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Acylcarnitines also play a role in detoxifying acyl-CoA intermediates by temporarily sequestering acyl groups, preventing their accumulation

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[1] Whilst Ozempic has demonstrated significant efficacy in glycaemic control and, in adults with type 2 diabetes and established cardiovascular disease, cardiovascular risk reduction, gastrointestinal side effects are amongst the most commonly reported adverse reactions

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Therefore, malnutrition, losses in dialysate, and kidney failure, as organs involved in the synthesis and reabsorption of carnitine, can all lead to carnitine deficiency in CKD patients