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This is mechanistically distinct from proton pump inhibitor pharmacology and is part of why the peptide attracts interest as a research tool for ulcer biology and NSAID-induced gastric injury
Lipo-B injections are not recommended during pregnancy or while breastfeeding
In a study by Malinda et al
Zebrafish have 3 ER types, one isoform of ER and two isoforms of ER (ER1 and ER2) which are encoded by different genes: esr1, esr2b , and esr2a respectively
While studies in animal models have shown promising results, more research in humans is needed to determine its safety for treating arthritis
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