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Mood and appetite, he explained, are closely related (think of stressful eating or eating when we are sad, comfort food), and a benefit of [GLP-1 drugs] is that they help control appetite and satiety, which allows patients to make better meal choices and become healthier. So, the modest improvement in depression seen in the study may be related to weight loss, improved blood sugars, [fewer diabetes] symptoms, and likely an overall sense of patients getting healthier, Splenser hypothesized

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After placebo adjustments were taken into account, the average weight loss was around 10.9%