Ipamorelin : 2nd-generation GHRP, highly selective for GHS-R1a, no significant impact on cortisol or prolactin the current darling of modern protocols GHRP-6 : first generation, potent but triggers marked hunger (ghrelin-like action on the arcuate nucleus) and slight prolactin/cortisol elevation Hexarelin : most potent on acute GH release, but rapid GHS-R1a desensitization after prolonged use and more pronounced cortisol elevation Key point: GHRPs add an amplifying signal that potentiates GHRH, but chronic monotherapy triggers receptor down-regulation
Mom of 3 Used for 6 weeks Verified What I didn't expect was how much easier everything else became once the cravings were under control
The most frequent were nausea, diarrhea, and anorexia
Clients often describe the sensation as similar to other standard injections, usually a quick, sharp pinch followed by slight soreness at the injection site
Evidence for an abnormal postprandial response to a high fat meal in women predisposed to obesity Am J Physiol 1994 267 : E549E559
These effects are similar to those observed with other poorly absorbed carbohydrates, such as sugar alcohols (polyols)
