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2015;23(suppl 2):S1-S26.doi:10.1002/oby.21140 Idrees Z, Cancarevic I, Huang L
Preclinical data further indicate that liraglutide activates the SIRT1 signaling cascade, suppresses atrophy-related genes, and upregulates myogenic differentiation factors, thereby protecting against obesity-induced muscle atrophy and contributing to structural muscle integrity [14, 16]
Even modest physical activitylike walking or light resistance trainingcan become more effective with creatine supplementation, enhancing muscle protein retention during a caloric deficit induced by GLP-1s
Strength training sessions can be adjusted to match energy levels and fitness experience
Two GLP analogs were recently approved for weight management
Recently, researchers conducted a cohort study using electronic medical records from a large, multinational population spanning 21 countries that compared the impact of GLP-1 receptor agonists and DPP-4 inhibitors on the risk of retinal vein occlusion (RVO) in these patients
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