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To this end, we expanded the generic human metabolic reconstruction Recon 2.2 19 by incorporating reactions specific to the substrates essential for the replication of the investigated viruses

and the advancement of innovative drug delivery systems, such as nanocarriers and hydrogels, that integrate strategies for regulating iron homeostasis, reducing inflammation, counteracting oxidative stress, and promoting cartilage regeneration

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A key property of glutathione homeostasis function is that increased oxidation, unless accompanied by appreciable consumption of GSH, is often followed or accompanied by increases in the total pool